Agenda

***Updated Sept 5th – some agenda details are tentative and subject to change***

Tuesday, October 2, 2018

4:00 PM – 9:00 PM
Registration – Edgewater Hotel-Olympic Ballroom

5:45 PM
Welcome Address
Nichole Klatt,
PhD, University of Miami, Miami, Florida

6:00 – 6:45 PM
Keynote 1: Basic Research in NHP Mucosal Transmission
Thomas Hope
, PhD, Northwestern University, Chicago, Illinois

6:45 – 7:30 PM
Keynote 2: Clinical Outcomes from NHP Studies
Dr. Irini Sereti
, MD, National Institute of Allergy & Infectious Diseases, Bethesda, Maryland

7:30 – 10:00 PM
Welcome Reception, Edgewater Hotel-Olympic Ballroom
Words from the “Berlin Patient” Cured of HIV – Timothy Ray Brown

Wednesday, October 3, 2018

7:00 AM – 3:00 PM
Registration – Foyer outside Bay Auditorium
Bell Harbor International Conference Center (BHICC)

7:00 AM – 12:00 PM
Poster Set up – Harbor Ballroom

7:30 – 8:45 AM
Continental Breakfast – Harbor Ballroom

8:00 AM – 5:00 PM
Sponsor Displays – Foyer

8:45 – 9:00 AM
Opening Remarks / Conference Co-Chairs – Bay Auditorium

Deborah Fuller, PhD, Core Staff, Washington National Primate Research Center, Seattle, Washington
Michael Gale, PhD, Core Staff, Washington National Primate Research Center, Seattle, Washington
Shiu-Lok Hu, PhD, Core Staff, Washington National Primate Research Center, Seattle, Washington
Nichole Klatt, PhD, University of Miami, Miami, Florida

SESSION I –
THE CURRENT EPIDEMIC: TRANSMISSIONS AND PREVENTION EFFORTS / PREVENTION NHP MODELS
Session Co-Chairs: Ian McGowan, Mauricio Martins

9:00 AM – 9:30 AM
New Infections and Prevention Efforts
Ian McGowan (Session Co-Chair)

9:30 AM – 10:15 AM
Session I Presentations

9:30 AM – 9:45 AM
Antibody Dependent Cell-Mediated Cytotoxicity in the Absence of Neutralization is Not Sufficient for Protection against Pathogenic SIV Challenge
Glen Grandea

9:45 AM – 10:00 AM
Immunogenicity and efficacy of MVA, gp145 vaccination against heterologous tier 2 SHIV C challenge in rhesus macaques
Diane Bolton

10:00 AM – 10:15 AM
Disruption of IL-15 signaling and NK cells facilitates gammaherpesvirus oncogenesis in SIV-infected rhesus macaques
Yoshinori Fukazawa

10:15 AM – 10:45 AM
Coffee Break – Foyer

10:45 AM – 11:15 AM
Vaccine protection against acquisition of SIVmac239 infection
Mauricio Martins (Session Co-Chair)

11:15 AM – 12:15 PM
Session I Presentations Continued

11:15 AM – 11:30 AM
BCG vaccination induced elevated levels of T cell and monocyte activation but was not associated with altered rates of oral SIV transmission in infant rhesus macaques
Matthew Wood

11:30 AM – 11:45 AM
Oral Antibiotic Classes Differentially Impact Longitudinal Vaginal Microbiome Stability and HIV Target Cell Levels in Rhesus Macaques
Andrew Gustin

11:45 AM – 12:00 PM
Tracking memory-like KLRC2 (NKG2C)+ NK cells in SIV and rhCMV infection in PBMC, Spleen and Colon of rhesus macaques
Daniel Ram

12:00 PM- 12:15 PM
CMV primes functional alternative signaling in memory-like NK cells but is subverted by lentivirus infection
Spandan Shah

12:15 PM – 2:00 PM
Lunch – Harbor Ballroom / Mentoring Lunch

SESSION II –
THE CURRENT EPIDEMIC: PATHOGENESIS, MORBIDITIES, MORTALITY /  NHP PATHOGENESIS
Session Co-Chairs: Peter Hunt, Jennifer Manuzak

2:00 PM – 2:30 PM
Morbidities, Mortality, Aging in HIV Infection
Peter Hunt (Session Co-Chair)

2:30 PM – 3:15 PM
Session II Presentations

2:30 PM – 2:45 PM
Characterization of TCR clonotype and transcriptional phenotype of unconventional MHC-E restricted T-cells at the single-cell level
Benjamin Bimber

2:45 PM – 3:00 PM
Brain memory CD4+ T cells: A potential new viral reservoir
Cheri Lee

3:00 PM – 3:15 PM
Innate lymphoid cell type 3 are depleted in the gastrointestinal, but not oral mucosae in lentivirus infection of adult and neonatal macaques
Brady Hueber

3:15 PM – 3:45 PM
Coffee Break – Foyer

3:45 PM – 4:15 PM
Mucosal immunity, microbiome and vaccination in NHPs
Jennifer Manuzak (Session Co-Chair)

4:15 PM – 5:15 PM
Session II Presentations Continued

4:15 PM – 4:30 PM
Antiretroviral Therapy does not Contribute to Intestinal Immune Dysfunction in Healthy Macaques
Alexandra Ortiz

4:30 PM – 4:45 PM
A novel macaque model of antiretroviral treatment with a combination of oral and long acting antiretroviral drugs
Michele Daly

4:45 PM – 5:00 PM
Signatures of Protective SIV-Specific CD8+ T-Cells

Carly Starke

5:00 PM – 5:15 PM
The human IL-15 superagonist complex N-803 drives SHIV-specific CD8+ T cells into B cell follicles in ART-suppressed rhesus macaques
Gabriela Webb

5:15 PM – 8:00 PM
Poster Reception – Harbor Ballroom
List of posters

Thursday, October 4, 2018

7:30 AM – 9:00 AM
Continental Breakfast – Harbor Ballroom

9:00 AM – 9:15 AM
Poster Awards – Bay Auditorium

SESSION III –
HIV PREVENTION MODELS AND OTHER INFECTIONS IN NHP
Session Co-Chairs: Dawn Dudley, Jonah Sacha, Michael Gale

9:15 AM – 9:45 AM
Human immune globulin treatment eliminates Zika viremia in pregnant rhesus macaques
Dawn Dudley (Session Co-Chair)

9:45 AM – 10:30 AM
Session III Presentations

9:45 AM – 10:00 AM
Transcriptomic host responses to RhCMV/SIV vaccines in protected and non-protected Rhesus macaques
Connor Driscoll

10:00 AM – 10:15 AM
RhCMV mediated vaccine protection predicted by using rule-based machine learning of transcriptomic profiles
Frank Barrenas

10:15 AM – 10:30 AM
Contribution of innate and anti-viral adaptive immune responses to ZIKV viral persistence and control in pigtail macaques
Megan O’Connor

10:30 AM – 11:00 AM
Coffee Break – Foyer

11:00 AM – 11:30 AM
Hepatitis B Virus: A New Model from an Old World Monkey
Jonah Sacha (Session Co-Chair) 

11:30 AM – 12:15 PM
Session III Presentations Continued

11:30 AM – 11:45 PM
CD8+ lymphocytes modulate acute ZIKV viremia, innate antiviral immunity and possibly tissue dissemination in nonhuman primates
Blake Schouest

11:45 PM – 12:00 PM
Transcriptomic analysis of fetal and dam tissues following Zika virus inoculation of pregnant nonhuman primates
Jenny Go

12:00 PM – 12:15 PM
Postnatal Zika virus infection causes persistent abnormalities in brain structure, function, and behavior in infant macaques: one year follow-up study

Maud Mavigner

12:15 PM – 2:00 PM
Lunch – Harbor Ballroom 

SESSION IV –
THE WAY AHEAD: CURE & THERAPEUTICS
Session Co-Chairs: Ann Chahroudi, Katharine Bar, Netanya Sandler Utay

2:15 PM – 2:30 PM  
Cure Approaches in Pediatric Populations
Ann Charoudi (Session Co-Chair) 

2:30 PM – 3:15 PM
Session IV Presentations

2:30 PM – 2:45 PM
Unique regulation of the DNA methylation machinery in natural hosts contributes to CD4 gene repression and SIV disease non-progression
Joseph Mudd

2:45 PM – 3:00 PM
Fully MHC-matched allogeneic hematopoietic stem cell transplantation in SIV-infected, cART-suppressed Mauritian cynomolgus macaques indicates GVHD as a reservoir clearance mechanism
Helen Wu

3:00 PM – 3:15 PM
Tissue Viral Burden Drives SHIV Pathogenesis in Infant Macaques and is Reduced by Early bNAb Therapy
Ann Hessell

3:15 PM – 3:45 PM
Coffee Break – Foyer

3:45 PM – 4:15 PM
NHP models to test HIV therapy and cure strategies
Katie Bar (Session Co-Chair)

4:15 PM – 5:15 PM
Session IV Presentations Continued

4:15 PM – 4:30 PM
Innate immune sensing and silence in HIV latent cells
Rebecca Olson

4:30 PM – 4:45 PM
In vivo effects of α4β7 blockade on size of viral reservoirs in SIV-infected rhesus macaques
Widade Ziani

4:45 PM – 5:15 PM
Advances in HIV Treatment
Netanya Sandler Utay (Session Co-Chair)

6:30 PM – 9:00 PM  
Banquet – Seattle Aquarium 

Friday, October 5, 2018

7:30 AM – 9:00 AM
Continental Breakfast – Harbor Ballroom 

SESSION V – BENCH TO BEDSIDE: TRANSLATING TO THE CLINIC
Session C0-Chairs: Grace Aldrovandi, Dan Barouch

9:00 AM – 9:30 AM
Translating to the Clinic
Grace Aldrovandi (Session Co-Chair)

9:30 AM – 10:15 AM  
Session V Presentations

9:30 AM – 9:45 AM
Evaluation of a Zika virus DNA vaccine in a pregnant rhesus macaque model of congenital Zika syndrome
Koen Van Rompay

9:45 AM – 10:00 AM
Gut microbiome dysbiosis after Zika virus infection is associated with increased peripheral and nervous system inflammation in macaques and humans
Charlene Miller

10:00 AM – 10:15 AM
Topical versus systemic TDF administration against SHIV transmission in Pigtail Macaques
Katarina Kotnik Halavaty

10:15 AM – 10:45 AM
Coffee Break – Foyer

10:45 AM – 11:15 AM
Parallel evaluation of a mosaic HIV vaccine candidate in NHPs and humans
Dan Barouch (Session Co-Chair)

11:15AM – 12:00 PM
Session V Presentations Continued

11:15 AM – 11:30 AM
Efficacy of Epithelial Stem Cell Vaccine to Induce Mucosal Immune Responses Protecting against Repeated Low Dose SIV Challenge
Marie-Claire Gauduin

11:30 AM – 11:45 AM
CD40L-adjuvanted VLP DNA prime/SOSIP trimer protein boost vaccination induces a strong GC-Tfh and autologous tier-2 neutralizing antibody responses in macaques
Amara Rama Rao

11:45 AM – 12:00 PM
Modifying CMV-specific T cells with anti-HIV CAR Vectors
Nathan Johnson

12:00 PM – 12:15 PM
Advances in minimally invasive serial tissue sampling in macaque models of HIV
Jeremy Smedley

12:15 PM – 12:30 PM
Preview of 2019 Symposium

12:30 PM
Closing Remarks